A Randomised Placebo Controlled Trial of ART Plus Dual Long-acting HIV-specific Broadly Neutralising Antibodies (bNAbs).

Inclusion Criteria21

• Aged ≥18 to ≤60 years old at screening
• Able to give informed written consent including consent to long-term follow-up
• Willing and able to comply with visit schedule and provide blood sampling
• Started ART within a maximum of six months of estimated time of primary infection. Estimated time of primary infection will be based on one of the following six criteria
• Positive HIV-1 serology within a maximum of 24 weeks of a documented negative HIV-1 serology test result (can include point of care test (POCT) using blood for both tests) - The estimated time of infection is taken as the midpoint between the dates of the negative HIV-1 serology or POCT test and positive HIV test at diagnosis
• The date of a positive p24 antigen result with or without a negative HIV antibody test depending on local laboratory reports
• The date of a negative antibody test with either detectable HIV RNA or proviral DNA
• PHE RITA test algorithm reported as "Incident" confirming the HIV-1 antibody avidity is consistent with recent infection (within the preceding 16 weeks). The estimated date of infection is assumed to be two months prior to the date of the incident test result. Asanté™ HIV-1 Rapid Recency® Assay can also be used for recency testing.
• The date of a weakly reactive or equivocal 4th generation HIV antibody antigen test
• Equivocal or reactive antibody test with \<4 bands on western blot
• OR, started ART in early stage infection, with nadir CD4 \> 500 cells and stable on ART with suppressed undetectable HIV VL 'target not detected' (TND) using local assays for \>= 1 years (a single viral load measurement \> 50 but \< 500 copies/mL during this time period is allowable)
• No evidence of viral insensitivity to either 10-1074 or 3BNC117 antibodies based on proviral sequencing algorithm
• HBV sAg or HBV DNA, HCV Ag or HCV RNA negative or anti-core antibody negative
• No significant co-morbidities
• Nadir CD4 \> 250 cells/μL for those diagnosed with confirmed PHI
• Current CD4 count \> 500 cells/µL or CD4:CD8 ratio \>1
• On integrase inhibitor (INSTI) or boosted protease inhibitor (PI) based regimen at time of randomisation, if previously on non-nucleoside reverse transcriptase inhibitor (NNRTI) has switched at least 4 weeks prior to randomisation
• Adequate haemoglobin (Hb≥12 g/dL for males, ≥11 g/dL for females)
• Weight ≥50 kg
• Have been vaccinated against coronavirus (COVID-19), at least 4 weeks prior to enrolment
• Females capable of becoming pregnant\* must agree to use hormonal contraception, intrauterine device, intrauterine hormone-releasing system, or to complete abstinence\*\* from at least two weeks before the first bNAb/placebo infusion and for 20 months after the last bNAb infusion.