Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
East Carolina University
100 participants
Mar 3, 2020
OBSERVATIONAL
Conditions
Summary
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
Eligibility
Inclusion Criteria4
- -50 years old
- BMI of 25 - 30 kg/m2
- BMI > 40kg/m2
- Lactate levels in top and lower 25%
Exclusion Criteria13
- Pregnant women
- Mentally disabled
- Prisoners
- Smokers
- Subjects with heart disease
- Type 1 and 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Peripheral occlusion
- Hepatic disease
- Have had weight fluctuations exceeding + 3% in the previous 12 months
- On medications which alter carbohydrate metabolism will not be studied
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Interventions
Severely obese women (BMI \>40) undergo sleeve gastrectomy
Locations(1)
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NCT04320264