RecruitingNCT04323904

Hantavirus Registry - HantaReg

Hantavirus Registry Gathers Knowledge on Epidemiology, Clinical Course, Prognostic Factors and Molecular Characteristics for Hantavirus Infections and Their Complications (HantaReg)

Sponsor

University of Cologne

Enrollment

200 participants

Start Date

Mar 4, 2020

Study Type

OBSERVATIONAL

Conditions

Hantavirus Infections Hemorrhagic Fever With Renal Syndrome Nephropathia Epidemica Hantavirus Cardiopulmonary Syndrome

Summary

Hantavirus disease are zoonotic infections and remain a clinical challenge with globally increasing incidence and multiple serious outbreak situations in Europe within the last years. Hantavirus disease encompasses two clinical syndromes, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) caused by Old World and New World hantaviruses, respectively. Depending on the causative Old World hantavirus species, clinical course of HFRS can vary from mild to moderate to severe. At present, there is no specific therapy available for hantavirus disease. As the clinical course of hantavirus disease is dependent on the causing viral pathogen and as there worrisome hints that clinical course HFRS and HCPS overlap, further studies with regard to the disease course are mandatory. Furthermore, the examination of attributable mortality and costs of hantavirus disease will need to be studied on a multinational basis and therefore HantaReg will particularly use a matched case control design.

Eligibility

Plain Language Summary

Simplified for easier understanding

HantaReg is an international registry study that collects data from patients who have been infected with hantavirus and developed kidney or cardiopulmonary disease. Hantaviruses are spread through contact with rodents or their droppings, and can cause serious diseases affecting the kidneys (hemorrhagic fever with renal syndrome) or the lungs and heart (hantavirus cardiopulmonary syndrome). By collecting detailed clinical information across many countries, researchers hope to better understand the course of these rare diseases, identify risk factors for serious illness, and improve treatment strategies. You may be eligible if: - You have laboratory evidence (blood test) confirming hantavirus infection - You have clinical signs of kidney disease caused by hantavirus (nephropathia epidemica or HFRS) - OR you have clinical signs of lung/heart disease caused by hantavirus (HCPS) You may NOT be eligible if: - You have a positive hantavirus test but have no symptoms of kidney or cardiopulmonary disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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