The Effect of Fluids on Aortic VTI During C-section
The Influence of Intravascular Fluid Administration on Aortic Velocity Time Integral in Obstetric Patients Undergoing Cesarean Section
Baylor College of Medicine
50 participants
Mar 25, 2020
OBSERVATIONAL
Conditions
Summary
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage. Accordingly, it is important to have an accurate method to assess fluid status in intrapartum patients. The use of standard volume assessment tools including arterial lines and central venous catheters is limited given the brevity of obstetric procedures and the morbidity of these techniques on the awake patients, and the costs. Non-invasive methods to assess volume status (carotid dopplers, direct measurement of blood loss, bio-impedance devices) are imperfect. Echocardiography is an attractive tool to measure fluid status in experienced operators such as anesthesiologists. IVC diameter and variation of aortic velocity time integral are two measures that can be obtained via echocardiography and been studied in spontaneously breathing patients. The purpose of this study is to determine whether these measurements can be used in the assessment of volume status in the laboring patient.
Eligibility
Inclusion Criteria5
- healthy nulliparous or multiparous pregnant women with a term (\>37 weeks gestation)
- age 18-35
- singleton pregnancy
- scheduled for Cesarean delivery with planned neuraxial spinal or combined spinal epidural anesthesia
- American Society for Anesthesiologists physical status 2
Exclusion Criteria6
- Patients without ability to provide informed consent
- American Society for Anesthesiologists physical status 3 or 4
- Emergency cesarean section
- BMI\>40
- Known cardiac and pulmonary comorbidities including chronic hypertension, preeclampsia, gestational hypertension, diabetes, asthma, renal disease
- Age \> 35
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Interventions
the intervention is one liter fluid bag of lactated ringers which is routinely used as a fluid coload for spinal anesthesia. All patients will receive the same amount of fluids however this will be paused at various time points in order to perform the echocardiogram.
Locations(1)
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NCT04330742