RecruitingNCT04330742

The Effect of Fluids on Aortic VTI During C-section

The Influence of Intravascular Fluid Administration on Aortic Velocity Time Integral in Obstetric Patients Undergoing Cesarean Section


Sponsor

Baylor College of Medicine

Enrollment

50 participants

Start Date

Mar 25, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage. Accordingly, it is important to have an accurate method to assess fluid status in intrapartum patients. The use of standard volume assessment tools including arterial lines and central venous catheters is limited given the brevity of obstetric procedures and the morbidity of these techniques on the awake patients, and the costs. Non-invasive methods to assess volume status (carotid dopplers, direct measurement of blood loss, bio-impedance devices) are imperfect. Echocardiography is an attractive tool to measure fluid status in experienced operators such as anesthesiologists. IVC diameter and variation of aortic velocity time integral are two measures that can be obtained via echocardiography and been studied in spontaneously breathing patients. The purpose of this study is to determine whether these measurements can be used in the assessment of volume status in the laboring patient.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how fluid given through a drip (intravenous fluids) during a caesarean section affects blood flow in the aorta — the body's main artery. When a spinal anaesthetic is given for a C-section, blood pressure can drop suddenly, which can be dangerous for both mother and baby. The way and timing of giving IV fluids may affect how well blood pressure is maintained. Blood flow is measured using a special device placed at the back of the throat (transoesophageal Doppler), providing real-time data on how fluids change aortic blood flow patterns during the procedure. You may be eligible if: - You are a healthy pregnant woman aged 18–35 - You are at least 37 weeks pregnant with a single baby - You are scheduled for a planned caesarean section under spinal or combined spinal-epidural anaesthesia - You are generally healthy (ASA physical status 2) You may NOT be eligible if: - You are having an emergency C-section - You have high blood pressure, pre-eclampsia, diabetes, asthma, heart or kidney problems - Your BMI is above 40 - You are over 35 years old - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGlactated ringers

the intervention is one liter fluid bag of lactated ringers which is routinely used as a fluid coload for spinal anesthesia. All patients will receive the same amount of fluids however this will be paused at various time points in order to perform the echocardiogram.


Locations(1)

Ben Taub General Hospital

Houston, Texas, United States

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NCT04330742


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