Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy

This study is testing a 'watch and wait' approach — combined with a focused local radiation treatment — for people with rectal cancer who cannot safely undergo surgery or chemotherapy due to other health conditions. Instead of surgery, researchers are monitoring whether the cancer responds to local treatment and remains stable. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer) confirmed by biopsy - Your tumor is accessible via a rectal exam or scope, located within 15 cm of the anus - Your cancer is stage T2–T3 with possible lymph node involvement - Your tumor is 5 cm or smaller and is not blocking the bowel - You are not a candidate for standard surgery or chemotherapy due to your health **You may NOT be eligible if...** - Your cancer type is not rectal adenocarcinoma (e.g., sarcoma, lymphoma) - You have evidence of cancer perforating through the bowel - You have already received radiation or chemotherapy for rectal cancer - Your tumor is fixed to surrounding structures and cannot be treated locally - You are eligible for standard surgery or another clinical trial Talk to your doctor to see if this trial is right for you.