Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

This study is testing whether inhibiting an enzyme called fatty acid synthase (FASN) — which cancer cells use to fuel their growth — can slow down castration-resistant prostate cancer that has already progressed after standard chemotherapy. The drug being studied works by blocking this energy pathway in tumor cells. **You may be eligible if...** - You are 18 years or older - You have prostate cancer that no longer responds to hormone therapy (castration-resistant) - You have already received docetaxel chemotherapy for your castration-resistant disease - Your cancer is progressing (rising PSA, new bone lesions, or lymph node growth) - You are in reasonably good physical condition (ECOG 0–2) - You agree to use contraception during and for 3 months after treatment **You may NOT be eligible if...** - You are currently taking another experimental drug - You have an allergy to omeprazole or taxane drugs - You have an uncontrolled infection, heart failure, unstable heart condition, or psychiatric illness that would prevent compliance Talk to your doctor to see if this trial is right for you.