UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions

This study is testing a precision radiation treatment for people with cancer that has spread to the brain (brain metastases). The technique — called image-guided, cognitive-sparing radiosurgery — targets tumors with high-dose radiation while deliberately avoiding areas of the brain responsible for memory and thinking, to help protect cognitive function. **You may be eligible if:** - You are 18 years or older - You have 1 to 3 brain metastases, each smaller than 3 cm - Your cancer originated from outside the brain (such as lung, breast, or prostate cancer) - You are in reasonably good health and can perform daily activities - Your life expectancy is greater than 6 months - You are able to undergo brain MRI scans - You can complete memory and thinking tests **You may NOT be eligible if:** - You are pregnant or nursing - You cannot have an MRI with contrast dye - The tumor is growing directly into brain areas that need to be protected - You are receiving chemotherapy on the same day as radiation - You have previously had whole-brain radiation therapy - Your cancer has spread to the lining of the brain (leptomeningeal disease) - Your cancer type is germ cell tumor, small cell carcinoma, or primary brain lymphoma Talk to your doctor to see if this trial is right for you.