RecruitingPhase 2NCT04346225

Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer

Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (13C) as a Diagnostic and Response Monitoring Imaging Tool in Advanced Prostate Cancer


Sponsor

Ivan de Kouchkovsky, MD

Enrollment

75 participants

Start Date

Jul 16, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective imaging study evaluating the utility of baseline metabolic MR imaging as a diagnostic and response monitoring tool in patients with advanced prostate cancer. Preliminary pre-clinical and clinical data demonstrates the ability of HP C-13 pyruvate/metabolic MR imaging to detect high-grade prostate cancer, including cancer with neuroendocrine differentiation, as well as provide early evidence of metabolic response and resistance following application of systemic therapies for the treatment of advanced prostate cancer patients. In the proposed study, the investigators aim is to extend the initial clinical results and further develop HP C-13 MRI as an imaging modality in advanced prostate cancer.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of MRI scan that uses a special molecule (hyperpolarized carbon-13 pyruvate) to track how tumors use energy. This metabolic imaging technique may reveal information about prostate cancer that standard scans cannot, helping doctors better understand tumor activity and treatment response. **You may be eligible if:** - You have confirmed locally advanced or metastatic prostate cancer - You have at least one tumor visible on standard scans that is large enough and in a location suitable for the new imaging technique - You have not had prior surgery to remove the prostate (for some imaging targets) **You may NOT be eligible if:** - You have certain implanted devices or conditions that prevent MRI scanning - Your target lesion is in the prostate and you have had the prostate surgically removed - You are unable to tolerate MRI procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHyperpolarized C13

Given by intravenous injection. When receiving two HP 13C pyruvate injections, the injections will be separated by a period of 15-60 minutes

PROCEDUREMagnetic Resonance Imaging (MRI)

Magnetic resonance imaging (MRI) is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body


Locations(1)

University of California, San Francisco

San Francisco, California, United States

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NCT04346225


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