Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis

This study tests whether fecal microbiota transplantation (FMT) — transplanting gut bacteria from a healthy donor, given as oral capsules — can help prevent flare-ups in adults with ulcerative colitis who are currently in remission. The capsules are freeze-dried for convenience. **You may be eligible if...** - You are 18 or older - You have a history of active ulcerative colitis in the past 12 months - Your disease is currently in remission (mild or no symptoms) and stable on your current medications - You are willing to attend all study visits and take the capsules as instructed - You have a doctor who is providing your regular care for UC **You may NOT be eligible if...** - You cannot swallow multiple capsules - You are pregnant, breastfeeding, or planning to become pregnant during the study - You have taken systemic antibiotics in the last 2 weeks - You have HIV, active hepatitis B, or hepatitis C - You have a history of recurrent C. difficile infection or FMT in the past 6 months - You have other bowel conditions such as celiac disease, diverticulitis, or a colostomy - You have a weakened immune system or are on high-dose steroids - Your life expectancy is less than 1 year Talk to your doctor to see if this trial is right for you.