Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

This study tests stereotactic radiosurgery (SRT) — a precise, targeted form of radiation delivered in a few sessions without surgery — for people who have multiple brain metastases (4 to 10 separate tumor spots in the brain) from any solid cancer. Current standard care for multiple brain tumors often involves whole-brain radiation, which can cause memory and cognitive side effects. **You may be eligible if...** - You are 18 or older - You have between 4 and 10 brain metastases confirmed on a recent MRI (within the past 4 weeks) - Each individual tumor is no larger than 3 cm, and the total tumor volume is 30 cm³ or less - Your overall health is reasonably good (Karnofsky score 70 or above) - Your cancer comes from a solid tumor (not lymphoma, multiple myeloma, germ cell tumor, or small cell lung cancer) - Your expected survival is more than 3 months **You may NOT be eligible if...** - You have had prior radiation or surgery on the same brain lesions being treated - You have cancer in the fluid surrounding the brain or spinal cord (leptomeningeal disease) - You have a large brainstem tumor (more than 20 cm³) - You are pregnant - You are currently receiving systemic cancer treatment - You have more than 10 brain tumors on the treatment MRI scan Talk to your doctor to see if this trial is right for you.