CBD-Microglia PET Study
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
Yale University
15 participants
May 7, 2021
INTERVENTIONAL
Conditions
Summary
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
Eligibility
Inclusion Criteria5
- Men and women aged 18- 55 years
- No significant medical or neurological illness
- No implanted metal devices that may pose a risk during MRI scanning
- Within the annual permissible radiation exposure
- Able to provide written informed consent.
Exclusion Criteria3
- Current use of any medications
- Presence of metal in the body
- Pregnancy or lactation
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Interventions
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Subjects will receive intravenous lipopolysaccharide.
A small dose of capsaicin will be administered by intradermal injection.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04398719