Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

This study is investigating whether problems with blood vessel function (specifically a molecule called endothelin) contribute to poor muscle energy production in people with Type 1 diabetes. **You may be eligible if...** - You are a man or premenopausal woman - You have been diagnosed with Type 1 diabetes (insulin-dependent) - You are otherwise in good general health **You may NOT be eligible if...** - You have liver, heart, or kidney disease - Your diabetes is poorly controlled (HbA1c above 12%) - You have diabetes complications such as nerve damage (neuropathy) - You have uncontrolled high blood pressure - You are currently a smoker Talk to your doctor to see if this trial is right for you.