RecruitingPhase 2NCT04450173

Obinutuzumab, Ibrutinib, and Venetoclax for the Treatment of Previously Untreated Stage II-IV Follicular Lymphoma

A Phase II Trial of the Combination of Obinutuzumab, Ibrutinib, and Venetoclax in Patients With Previously Untreated Follicular Lymphoma


Sponsor

Joseph Tuscano

Enrollment

40 participants

Start Date

Feb 24, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial studies how well obinutuzumab, ibrutinib, and venetoclax work in treating patients with previously untreated stage II-IV follicular lymphoma. Immunotherapy with obinutuzumab may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Ibrutinib and venetoclax may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving obinutuzumab, ibrutinib, and venetoclax together may work better in treating follicular lymphoma compared to each drug alone.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of three drugs — obinutuzumab, ibrutinib, and venetoclax — as a first treatment for follicular lymphoma (a slow-growing type of blood cancer) without using traditional chemotherapy. **You may be eligible if...** - You have been newly diagnosed with follicular lymphoma (grades 1, 2, or 3a) and have not yet received any treatment - Your lymphoma is measurable on scans and requires treatment - You are 18 or older and in adequate overall health **You may NOT be eligible if...** - Your lymphoma has transformed into a more aggressive type - You have grade 3b follicular lymphoma - You have active lymphoma in the central nervous system or spinal fluid - You have had prior treatment for follicular lymphoma - You have significant heart rhythm problems or are on certain blood thinners Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIbrutinib

Given PO

BIOLOGICALObinutuzumab

Given IV

DRUGVenetoclax

Given PO


Locations(4)

University of California, San Francisco (UCSF) Fresno

Fresno, California, United States

University of California, Los Angeles

Los Angeles, California, United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

University of California, San Diego

San Diego, California, United States

View Full Details on ClinicalTrials.gov

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NCT04450173


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