RecruitingNot ApplicableNCT04452305

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting


Sponsor

University of Pittsburgh

Enrollment

10 participants

Start Date

Nov 10, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.


Eligibility

Sex: MALE

Plain Language Summary

Simplified for easier understanding

This study offers a chance for men who had their testicular tissue frozen before cancer treatment (such as chemotherapy or radiation) to have that tissue transplanted back into their body. The goal is to help restore fertility that may have been lost due to cancer treatment. **You may be eligible if:** - You are male and have gone through at least the early stages of puberty (Tanner stage 3 or above) - You previously had testicular tissue or cells frozen because your cancer diagnosis or treatment put your fertility at risk - You are healthy enough to undergo anesthesia - Your cancer doctor has confirmed you have finished treatment and are cleared for this procedure **You may NOT be eligible if:** - You are considered high-risk for surgical complications - You have a history of leukemia, lymphoma, testicular cancer, or another cancer that may have spread to the testicles at the time tissue was collected - You have a psychological or psychiatric condition that prevents you from giving informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESpermatogonial Stem Cell Transplant and Testicular Tissue Grafting

Spermatogonial stem cell transplant and testicular tissue grafting is performed to produce sperm.


Locations(1)

Magee-Womens Hospital

Pittsburgh, Pennsylvania, United States

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NCT04452305


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