Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

This study is testing whether injecting a local anesthetic near the femoral artery can control a type of high blood pressure that occurs during ankle replacement surgery when a tourniquet (a tight band used to stop blood flow) is applied to the leg. **You may be eligible if:** - You are between 18 and 75 years old - You are scheduled to have total ankle replacement surgery - You are in reasonably good health (not classified as critically ill) - You can communicate your pain levels during and after surgery **You may NOT be eligible if:** - You have chronic pain or use opioid pain medications daily - You are pregnant - You have an allergy to local anesthetic medications - You weigh less than 50 kg (about 110 lbs) - You have a history of substance or alcohol abuse in the past 2 years - You have uncontrolled anxiety, schizophrenia, or other psychiatric conditions - You have a significant medical condition that increases your surgical risk Talk to your doctor to see if this trial is right for you.