RecruitingNot ApplicableNCT04458532

Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer

A Randomized Trial to Minimize Non-Response to Aerobic Training in Post-Menopausal Women With Early Stage Breast Cancer


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

152 participants

Start Date

Oct 8, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and can be performed for at least 10 minutes. The researchers will study the effects of different exercise programs on how well the study participants' bodies use oxygen, how well their heart pumps blood, how well their lungs function, and how healthy their blood vessels are.


Eligibility

Sex: FEMALEMin Age: 21 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured exercise program can improve heart health in post-menopausal women who have finished treatment for early-stage breast cancer. Many breast cancer survivors have reduced fitness after treatment, and this study explores if targeted exercise can reverse that decline. **You may be eligible if:** - You are a female aged 21–80 - You had early-stage breast cancer (stages I–III) that was surgically removed - You are post-menopausal (naturally, chemically, or surgically) - You completed all cancer treatment at least 1 year ago but no more than 5 years ago - Your exercise capacity (measured by a cardiopulmonary exercise test) is below normal for your age **You may NOT be eligible if:** - You have significant heart problems, uncontrolled high blood pressure, or other conditions that make exercise unsafe - You are currently pregnant - Your cancer has returned or spread - You are unable to perform the required exercise testing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAerobic Training

300 min/wk for 16 weeks

OTHERAerobic Training

150 min/wk for 32 weeks

OTHERAerobic Training

300 min/wk for 32 weeks

OTHERAerobic Training

150 min/wk for 16 weeks


Locations(2)

Hartford Healthcare Cancer Institute @ Hartford Hospital (Data Collection Only)

Hartford, Connecticut, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

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NCT04458532


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