RecruitingNCT04460950

Observational Study for the Evaluation of Incidence of Familial AML/MDSs in Patients With Myeloid Neoplasms

A Retrospective and Prospective Multicentre Observational Study for the Evaluation of Incidence of Familial AML/MDSs in Patients With Myeloid Neoplasms (AML/MDS)

Sponsor

Gruppo Italiano Malattie EMatologiche dell'Adulto

Enrollment

237 participants

Start Date

Dec 16, 2020

Study Type

OBSERVATIONAL

Conditions

Acute Myeloid Leukemia Familial Acute Myeloid Leukemia Myelodysplastic Syndromes

Summary

Observational study aimed at evaluating the incidence of familial AML/MDSs in patients with de novo MDSs or AML with almost one relative affected by hematologic neoplasms and/or other cancers at young age (\< 40 years)

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how often leukemia and myelodysplastic syndromes (blood cancers affecting bone marrow) run in families, and whether inherited gene mutations are responsible. Understanding family patterns can help identify people at higher genetic risk. **You may be eligible if:** - You are over 18 years old - You have been diagnosed with AML (acute myeloid leukemia) or MDS (myelodysplastic syndrome) between January 2014 and December 2022 - At least one close relative (first or second degree) has been diagnosed with a blood cancer or myeloid disease, OR a relative was diagnosed with a solid tumor before age 40, OR you have signs that suggest an inherited blood cancer syndrome - You have signed informed consent **You may NOT be eligible if:** - There are no specific exclusion criteria for this study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(27)

Aon Ss. Antonio E Biagio E C. Arrigo - Alessandria - Soc Ematologia

Alessandria, Italy

Aou Ospedali Riuniti "Umberto I - G.M. Lancisi - G. Salesi"- Ancona - Sod Clinica Ematologica

Ancona, Italy

Ao Di Rilievo Nazionale E Di Alta Specialità "San Giuseppe Moscati" - Avellino - Uoc Ematologia Con Unità Di Trapianto

Avellino, Italy

Asl Caserta, Presidio Ospedaliero S.G.Moscati - Aversa - Uo Oncoematologia

Aversa, Italy

Aou Di Bologna - Policlinico S. Orsola-Malpighi - Uoc Ematologia

Bologna, Italy

Asst Degli Spedali Civili Di Brescia - Ssvd Centro Trapianti Midollo Per Adulti - Cattedra Di Ematologia

Brescia, Italy

Asst Degli Spedali Civili Di Brescia - Uo Ematologia

Brescia, Italy

Ao Brotzu, Presidio Ospedaliero A. Businco - Cagliari - Sc Ematologia E Ctmo

Cagliari, Italy

Aou Ospedali Riuniti - Foggia - Uoc Ematologia

Foggia, Italy

Asl Lecce, Ospedale 'V. Fazzi' - Uo Ematologia

Lecce, Italy

Ao Ospedali Riuniti "Papardo Piemonte" - Po Papardo - Messina - Sc Ematologia

Messina, Italy

Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia

Milan, Italy

Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico - Milano - Ematologia - Padiglione Marcora

Milan, Italy

Aou San Luigi Gonzaga - Orbassano - Scdu Ematologia Generale E Oncoematologia

Orbassano, Italy

Asl Salerno, Presidio Ospedaliero Tortora Pagani - Ematologia

Pagani, Italy

Aou Policlinico P. Giaccone - Palermo - Uo Ematologia

Palermo, Italy

Aou Di Parma - Sc Ematologia E Centro Trapianti Midollo Osseo

Parma, Italy

Ao Di Perugia, Ospedale S. Maria Della Misericordia - Ematologia E Trapianto Midollo Osseo

Perugia, Italy

Aou Pisana - Uo Ematologia Universitaria

Pisa, Italy

Ausl Di Reggio Emilia - Arcispedale Santa Maria Nuova, Irccs - Sc Ematologia

Reggio Emilia, Italy

Ausl Della Romagna, Ospedale "Infermi" - Rimini - Uo Ematologia

Rimini, Italy

Asl Roma 2, Ospedale S. Eugenio- Ospedale S.Eugenio - Uoc Ematologia

Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli Irccs - Roma - Area Ematologica

Roma, Italy

Ente Ecclesiastico Casa Sollievo Della Sofferenza - San Giovanni Rotondo - Ematologia

San Giovanni Rotondo, Italy

Aou Di Sassari - Cliniche Universitarie - Stabilimento Cliniche Di San Pietro - Uoc Ematologia

Sassari, Italy

Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia - Università Degli Studi Di Torino

Torino, Italy

Asui Di Udine - Presidio Ospedaliero "Santa Maria Della Misericordia" - Clinica Ematologica

Udine, Italy

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NCT04460950

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