EBRT and HDR Brachytherapy for Unfavorable-intermediate, High, and Very High-risk Prostate Cancer

This study is looking at the outcomes of combining external beam radiation therapy (a standard radiation approach) with high-dose-rate brachytherapy (placing radioactive seeds directly inside the prostate) for men with intermediate or high-risk prostate cancer. Researchers want to see how well this combined approach works and what side effects patients experience. **You may be eligible if:** - You are a man aged 18 or older - You have a confirmed prostate cancer diagnosis within the last year - Your prostate cancer is classified as unfavorable-intermediate, high, or very high risk (by NCCN guidelines) - Your PSA level was below 50 ng/mL before any hormone therapy - You are in good general health (ECOG 0 or 1) - You have had a pelvic MRI within the past 12 months **You may NOT be eligible if:** - Your cancer has spread to the bones - You have had a previous prostate removal surgery or prostate cryosurgery - You have had previous pelvic radiation or prostate seed implants - You have another active cancer (other than minor skin cancers), unless you have been cancer-free for at least 3 years Talk to your doctor to see if this trial is right for you.