RecruitingNCT04478006

Advanced Translational Research on Childhood Leukemia

Driving Therapeutic Progress of Childhood Leukemia Through Advanced Translational Research With Immediate and Long-term Impact. Precision Medicine for Childhood Leukemia.

Sponsor

Chinese University of Hong Kong

Enrollment

300 participants

Start Date

Jul 1, 2020

Study Type

OBSERVATIONAL

Conditions

Childhood Leukemia

Summary

Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of \<50%, which is unlikely to be boosted by intensification of standard chemotherapy due to overwhelming toxicity. The advent of effective and safe targeted therapies for high-risk cases is therefore imperative. This study constitutes two research projects aiming at driving therapeutic advances.

Eligibility

Max Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This research study collects biological samples and data from children with leukemia and related blood cancers to advance understanding of these diseases. It also includes healthy bone marrow donors as a comparison group. The goal is to discover better treatments for childhood leukemia. **You may be eligible if...** - Your child has been diagnosed with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), mixed phenotype acute leukemia, juvenile myelomonocytic leukemia (JMML), or myelodysplastic syndromes (MDS) - You are a normal bone marrow donor - You or your child can communicate in English or Chinese **You may NOT be eligible if...** - You or your child is unable to communicate in English or Chinese - The patient or parent refuses to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICRNA-seq

Gene expression and fusion transcripts analysis

GENETICwhole exon sequencing

Genetic alternation analysis

OTHERCytogenetics test

Remission and relapse are monitored by cytogenetic analyses.

Locations(1)

Hong Kong Children Hospital

Hong Kong, Hksar, China

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