NBTXR3 Activated by Radiation Therapy for the Treatment of Locally Advanced or Borderline-Resectable Pancreatic Cancer

This study tests NBTXR3 — tiny radioactive particles injected directly into a tumor — combined with standard radiation therapy for patients with locally advanced or borderline-resectable pancreatic cancer, meaning cancer that may or may not be operable. The goal is to shrink tumors enough to allow surgery. **You may be eligible if...** - You are 18 or older with biopsy-proven pancreatic adenocarcinoma - Your cancer is locally advanced or borderline resectable (it involves nearby blood vessels but has not spread widely) - You are able to provide informed consent **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have not had a biopsy confirming pancreatic adenocarcinoma - You have significant health conditions that would make radiation or injection unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.