RecruitingNCT04494295

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation


Sponsor

Integra LifeSciences Corporation

Enrollment

500 participants

Start Date

Oct 23, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

This registry will study the use of the Aurora® Surgiscope to provide surgical access and visualization in minimally invasive removal of hematoma in the brain. Many methods of hematoma removal are available and will be based on surgeon preference. The impact of patient selection and time to surgery from last known well time will be explored.


Eligibility

Min Age: 18 Years

Inclusion Criteria6

  • Subject Age is > 18
  • Subject with a Head CT that demonstrates an acute, spontaneous, primary, supratentorial ICH of volume > 20 mL, assessed via standard of care techniques
  • Subject Surgery can be initiated within 24 hours of the last known well time or, in patients with wake-up onset, within 24 hours of the time the patient awoke with symptoms.
  • Subject has a NIHSS score > 5
  • Subject has a baseline Modified Rankin Scale (mRS) Score ≤ 2
  • Subject with a CT Angiography demonstrating no vascular malformation

Exclusion Criteria9

  • Subject has an underlying vascular lesion defined as causative source of ICH
  • Subject has a profound neurological deficit defined as fixed/dilated pupils or bilateral extensor motor posturing
  • Subject has an Infratentorial or brainstem ICH
  • Subject has a known life expectancy < 6 months
  • Subject has an uncorrectable coagulopathy
  • Subject has a mechanical heart valve
  • Subject is pregnant
  • Subject participates in another concurrent interventional clinical trial
  • Subject who is unable to meet study follow-up requirements

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Interventions

DEVICEAurora Surgiscope System

MIS evacuation of hematoma using the Aurora Surgiscope System


Locations(20)

Providence Health

Burbank, California, United States

University of Miami

Miami, Florida, United States

University of South Florida

Tampa, Florida, United States

Rush University Medical Center

Chicago, Illinois, United States

MedStar Health Research Institute

Baltimore, Maryland, United States

Corewell Health

Grand Rapids, Michigan, United States

University of Missouri

Columbia, Missouri, United States

Washington University in St. Louis

St Louis, Missouri, United States

JFK university

Edison, New Jersey, United States

University at Buffalo

Buffalo, New York, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

University of North Carolina

Chapel Hill, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

University of Oklahoma

Oklahoma City, Oklahoma, United States

Pennsylvania State University

Hershey, Pennsylvania, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Prisma Health - Upstate

Greenville, South Carolina, United States

UT Health

Houston, Texas, United States

University of Utah

Salt Lake City, Utah, United States

University of Washington - Harborview

Seattle, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT04494295