Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)

This study examines patients who have both severe mitral valve regurgitation (a leaky heart valve) AND atrial fibrillation (an irregular heart rhythm), and who are undergoing a minimally invasive procedure to repair the valve (MitraClip). It tests whether adding a left atrial appendage closure device (WATCHMAN) during the same procedure reduces the risk of stroke. **You may be eligible if...** - You are 18 or older with severe symptomatic mitral regurgitation meeting criteria for MitraClip - You also have documented atrial fibrillation and meet criteria for the WATCHMAN device - You are eligible for short-term anticoagulation therapy - You are willing and able to attend required follow-up visits **You may NOT be eligible if...** - Your mitral valve anatomy is not suitable for the MitraClip procedure - You cannot tolerate anticoagulation - You have active infection or other significant cardiac conditions Talk to your doctor to see if this trial is right for you.