RecruitingPhase 2Phase 3NCT04499898

Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding

Randomized Controlled Trial of Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding in Cirrhotic Patients With Arterial Hypertension

Sponsor

Sherief Abd-Elsalam

Enrollment

306 participants

Start Date

Oct 1, 2018

Study Type

INTERVENTIONAL

Conditions

Esophageal Varices

Summary

Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension

Eligibility

Min Age: 18 Years

Inclusion Criteria3

• Aged \>18 years
Cirrhotic patients with arterial hypertension
Endoscopic evidence of medium/large-sized esophageal varices

Exclusion Criteria10

• History of variceal bleeding or previous primary prevention of varices.
Portal vein thrombosis or previous porto-systemic shunts as TIPS.
Patients on drugs affecting portal pressure (beta blockers, nitrates).
Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia.
Patients with severe respiratory diseases (COPD, bronchial asthma).
Uncontrolled diabetes mellitus
Renal impairment
Hepatocellular carcinoma
Allergy to carvedilol
Pregnancy or lactation