Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

This study tests whether giving a concentrated course of radiation therapy (hypofractionated radiotherapy) before surgery improves outcomes for people with soft tissue sarcoma — a type of cancer that grows in muscles, fat, nerves, or connective tissue — in the limbs, pelvis, chest wall, or trunk. **You may be eligible if...** - You have been diagnosed with soft tissue sarcoma of the arm, leg, pelvis, chest wall, or trunk (not in the abdomen/retroperitoneum) - You are well enough to tolerate radiation and surgery (ECOG status 0–2) - Your medical team has determined surgery is possible **You may NOT be eligible if...** - You have had prior radiation to the same area - You are pregnant - You have active collagen vascular disease (such as lupus or scleroderma) - Your sarcoma is in the retroperitoneum (back of the abdomen) Talk to your doctor to see if this trial is right for you.