The Relapse from MRD Negativity As Indication for Treatment (REMNANT) Study

This study is looking at the best time to restart treatment in newly diagnosed multiple myeloma patients who achieve complete remission (no detectable cancer) after stem cell transplant, but then show early signs that the disease may be returning. **You may be eligible if...** - You have been newly diagnosed with multiple myeloma - You are between 18 and 75 years old and eligible for high-dose chemotherapy and stem cell transplant - You have achieved a deep remission (MRD negative status) after treatment - You later show signs of early disease return on sensitive testing **You may NOT be eligible if...** - You have significant other health conditions that would make participation unsafe - You cannot tolerate the study treatment regimens - You have had a prior stem cell transplant for a different condition Talk to your doctor to see if this trial is right for you.