Longitudinal Neuroimaging in Sturge-Weber Syndrome
Wayne State University
80 participants
Mar 1, 2020
INTERVENTIONAL
Conditions
Summary
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.
Eligibility
Inclusion Criteria7
- Subjects with Sturge-Weber syndrome (SWS):
- Age 3 months - 30 years;
- Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
- In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
- Healthy control subjects:
- Age 3 years - 30 years;
- No history of neurological or psychiatric disorder
Exclusion Criteria6
- For all subjects:
- Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
- History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes.
- Pregnancy (pregnant women will be scheduled for the study after delivery).
- History of sensitivity to MRI contrast material;
- History of renal disease that would preclude safe administration of MRI contrast material
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Interventions
Brain magnetic resonance imaging (MRI) will be done using multiple sequences to evaluate presence, type and severity of brain abnormalities in enrolled subjects.
Participants will undergo age-appropriate neuro-psychology testing to assess motor, language and other neuro-cognitive functions potentially affected by Sturge-Weber syndrome.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04517565