RecruitingPhase 2NCT04519151

Pembrolizumab and Lenvatinib for Platinum- Sensitive Recurrent Ovarian Cancer

A Phase II, Open Lable, Single Arm, Trial to Determine Efficacy and Safety of Lenvatinib in Combination With Pembrolizumab for Platinum- Sensitive Recurrent Ovarian Cancer


Sponsor

Sheba Medical Center

Enrollment

24 participants

Start Date

Apr 12, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a study of pembrolizumab (MK-3475, KEYTRUDA®) in combination with lenvatinib (E7080) for the treatment of platinum sensitive recurrent ovarian cancer. Participants will receive pembrolizumab and lenvatinib.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining two drugs — pembrolizumab (an immunotherapy) and lenvatinib (a targeted therapy that cuts off blood supply to tumors) — can help women with recurrent ovarian cancer that previously responded to platinum-based chemotherapy. **You may be eligible if...** - You are female and at least 18 years old - You have been diagnosed with ovarian cancer (epithelial type, excluding low-grade or mucinous subtypes) - Your cancer came back at least 6 months after platinum-based chemotherapy (platinum-sensitive) - You are not pregnant or breastfeeding **You may NOT be eligible if...** - You have low-grade or mucinous ovarian cancer - You are pregnant or breastfeeding - You have significant heart, liver, or autoimmune conditions - You have previously received certain immunotherapy treatments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPembrolizumab

200 mg administered by IV infusion on Day 1 of each 21-day cycle.

DRUGLenvatinib

20 mg administered orally (PO) QD during each 21-day cycle.


Locations(1)

Sheba Medical center

Ramat Gan, Israel

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NCT04519151


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