Effects of 5HTP on the Injured Human Spinal Cord
Effects of the Serotonin Precursor, 5-hydroxytryptophan, in the Injured Human Spinal Cord
University of Alberta
30 participants
Jul 1, 2020
INTERVENTIONAL
Conditions
Summary
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Eligibility
Inclusion Criteria1
- participants must have suffered trauma to the spinal cord at least six months ago or longer
Exclusion Criteria36
- individuals with damage to the nervous system other than to the spinal cord
- pregnant and/or breastfeeding women
- alcoholic participants
- history of seizure/epilepsy
- history of suicidal thoughts or behaviors
- known or suspected allergy to the medication ingredients
- cardiovascular disease including history of heart attack or heart rhythm irregularities
- coronary artery disease
- reduced liver function or disease
- reduced kidney function or disease
- lung disease
- comatose or depressed states due to CNS depressants
- endocrine dysfunction
- blood dyscrasias or blood related disease
- bone marrow depression
- hypocalcemia
- history of stomach ulcers
- wide angle glaucoma
- phenylketonuria
- history of tumors
- uncontrolled heart problems
- unstable psychiatric or mental disorder
- Participants taking:
- monoamine oxidase inhibitor therapy
- serotonergic antidepressants
- tricyclic antidepressants
- any type of serotonergic agonist
- dopamine D2 receptor antagonists
- amphetamine
- CNS depressants
- levodopa
- lithium
- anti-hypertensive drugs
- iron salts
- metoclopramide
- phenothiazine medication
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Interventions
100mg combined with 50mg carbidopa
50mg combined with 50mg carbidopa
50mg
Placebo
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04520178