Dumping Syndrome and Esophageal Atresia
Physiopathology of Dumping Syndrome in Esophageal Atresia
University Hospital, Lille
15 participants
Feb 23, 2024
INTERVENTIONAL
Conditions
Summary
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months
Eligibility
Inclusion Criteria3
- Patients operated at birth for Oesophageal atresia type C
- Aged from 2 to 3 months at inclusion
- Off prokinetic treatment (suspended for at least 72 hours) before monitoring
Exclusion Criteria3
- History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..)
- History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete)
- Treatment that can modify gastric motility
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Interventions
Continuous glycaemia monitoring,
Fasting administration of a Technecium-labelled milk bottle and quantification of the remaining radioactivity by a camera every 30 minutes for 4 hours.
continuous cardiac monitoring
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT04522193