Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

This study uses a device called CIVO to inject tiny (microdose) amounts of multiple anti-cancer drugs directly into a tumor at once, allowing doctors to see which drug works best in that specific tumor — all before the patient starts full systemic treatment. **You may be eligible if...** - You are 18 or older - You have a confirmed solid tumor diagnosis (specific tumor types are listed in each sub-study) - You have at least one tumor that is accessible on the surface of the skin or in a lymph node - You are willing and able to complete study visits and procedures **You may NOT be eligible if...** - Your tumor cannot be safely accessed for injection - You have serious health conditions that prevent participation - You are unable or unwilling to provide written consent Talk to your doctor to see if this trial is right for you.