RecruitingNCT04544969

Detecting Chemosensitivity and Predicting Treatmemt Efficacy With CTCs in mNPC

Detecting Chemosensitivity and Predicting Treatmemt Efficacy With Circulating Tumour Cells From Peripheral Blood in Metastatic Nasopharyngeal Carcinoma Patients


Sponsor

Sun Yat-sen University

Enrollment

50 participants

Start Date

Apr 1, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

The prospective observational clinical study will recruit 50 metastatic nasopharyngeal carcinoma (mNPC) patients, detecting patient's chemosensitivity with the circulating tumor cells (CTCs) from peripheral blood and prdicting patient's treatment efficacy with CTCs dynamic change.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether measuring circulating tumor cells (cancer cells that have broken off and entered the bloodstream) can predict how well chemotherapy will work in patients with nasopharyngeal carcinoma (a cancer at the back of the nose and throat) that has spread to other parts of the body. **You may be eligible if...** - You have nasopharyngeal carcinoma that has spread to distant organs, at least 3 months after completing radiation therapy - You are not a candidate for local treatment - You are between 18 and 70 years old - You are in good general health (ECOG score 0–1) - You have at least one measurable area of disease on imaging - Your expected survival is at least 3 months **You may NOT be eligible if...** - You have another active malignancy - You are currently enrolled in another clinical trial - You have drug or alcohol dependency issues - Your blood counts or organ function are significantly abnormal Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGcisplatin-based chemotherapy

GP: cisplatin 80 mg/m2 intravenous infusion on day1, gemcitabine 1000 mg/m2 intravenous infusion on day 1 and 8, both drugs are given every 3 weeks, recommended 6 cycles. TP: cisplatin 75 mg/m2 intravenous infusion in day1, docetaxel 75 mg/m2 intravenous infusion in day 1, both drugs are given every 3 weeks, recommended 6 cycles. PF: cisplatin 100 mg/m2 intravenous infusion in day1, fluorouracil 4000 mg/m2 intravenous infusion in day 1 to 5, both drugs are given every 3 weeks, recommended 6 cycles. TPF: cisplatin 60 mg/m2 intravenous infusion in day1, docetaxel 60 mg/m2 intravenous infusion in day 1, fluorouracil 3000 mg/m2 intravenous infusion in day 1 to 5, both drugs are given every 3 weeks, recommended 6 cycles. Choice of chemotherapy regimen is decided by patient's doctor in charge.


Locations(1)

Cancer Center, Sun Yat-sen University

Guangzhou, Guangdong, China

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NCT04544969


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