RecruitingPhase 1NCT04545762

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

A Phase 1 Clinical Trial of Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma


Sponsor

C. Babis Andreadis

Enrollment

36 participants

Start Date

Sep 11, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This study will assess safety and feasibility of infusing genetically modified autologous T cells transduced to express a chimeric antigen receptor targeting the B cell surface antigen Cluster of Differentiation 19 (CD19).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a CAR-T cell therapy that targets the CD19 protein on cancer cells in patients with relapsed or hard-to-treat non-Hodgkin lymphoma (NHL), including Burkitt lymphoma and other aggressive B-cell lymphomas. **You may be eligible if...** - You have a diagnosis of relapsed or refractory Burkitt lymphoma or another eligible B-cell lymphoma subtype - You have received at least one prior treatment that included both an anti-CD20 antibody (like rituximab) and an anthracycline chemotherapy - Your disease is measurable on a PET scan - There are no significant amounts of cancer cells circulating in your blood **You may NOT be eligible if...** - Your lymphoma is not CD19-positive - You have active central nervous system lymphoma involvement in certain locations - You have significant organ dysfunction or active infections - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFludarabine

Given intravenously (IV)

DRUGCyclophosphamide

Given intravenously (IV)

BIOLOGICALanti-CD19 CAR-T cells

Single infusion


Locations(1)

University of California, San Francisco

San Francisco, California, United States

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NCT04545762


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