Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)

This study is evaluating a new PET scan imaging agent called [18F]FNP-59 that tracks cholesterol movement in the adrenal glands — both in healthy volunteers and in patients with adrenal hormone disorders — to better understand adrenal gland function. **You may be eligible if...** - For Groups 2 and 3: You are a healthy adult with no known adrenal gland disease, willing to undergo a specific hormonal manipulation followed by PET imaging - For Group 4: You have been diagnosed with an adrenal condition involving abnormal hormone secretion - You are able to provide your own consent and undergo imaging - You weigh under 400 lbs (181 kg) **You may NOT be eligible if...** - You are pregnant - You have a known adrenal problem (for healthy volunteer groups) - You use steroids, hormonal medications, or certain blood pressure drugs (ACE inhibitors/ARBs) - You are a prisoner Talk to your doctor to see if this trial is right for you.