RecruitingPhase 2Phase 3NCT04549610

HMB and Exercise-induced Muscle Damage

The Effect of β-hydroxy-β-methylbutyrate Supplementation on Muscle Damage Induced by Resistance Exercise


Sponsor

Poznan University of Physical Education

Enrollment

30 participants

Start Date

Nov 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims at assessing the influence of β-hydroxy-β-methylbutyrate (HMB) supplementation (4.0 g/day) supplemented for 7 days in a group of speed-strength trained individuals on lower-body strength performance, selected muscle histological, molecular and blood markers of muscle recovery in response to resistance exercise-induced muscle damage.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether taking HMB (beta-hydroxy beta-methylbutyrate), a supplement derived from the amino acid leucine, can reduce exercise-induced muscle damage. When you do intense strength training, your muscles experience microscopic tears, leading to soreness and temporary strength loss. HMB is thought to speed up recovery and reduce this damage. The study is aimed at trained male athletes aged 18 to 35 who regularly do strength training involving the legs. Participants need to already be consuming enough protein in their diet and be able to lift at least 2.5 times their body weight in a leg press. They will follow a structured exercise and supplementation protocol and be assessed for markers of muscle damage. You may be eligible if: - You are a male aged 18 to 35 - You have at least 1 year of strength training experience that includes lower body workouts - You train at least 3 times per week - Your protein intake is above 1.6g per kg of body weight per day - You can leg press at least 2.5 times your body weight You may NOT be eligible if: - You currently have an injury - You smoke or use tobacco - You have taken creatine, caffeine, beta-alanine, or other ergogenic supplements in the past 3 months - You have used anabolic steroids or performance-affecting drugs - You have had an infectious disease in the past 4 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTHMB supplementation

Group taking oral HMB supplementation in a blinded capsule form.

DIETARY_SUPPLEMENTPlacebo treatment

Group taking oral supplementation with placebo (corn starch) in a blinded capsule form.


Locations(1)

Escola de Educação Física e Esporte da USP / School of Physical Education and Sport - USP.

São Paulo, São Paulo - SP, Brazil

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NCT04549610


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