Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

This study tests a brain stimulation technique using low-intensity focused ultrasound (like very gentle sound waves aimed at a specific brain region) to treat generalized anxiety disorder (GAD) in people whose anxiety has not improved with medications. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with moderate-to-severe generalized anxiety disorder (GAD) lasting more than one year - You have tried and not responded to at least 2 different SSRI medications and one additional treatment - You are medically stable **You may NOT be eligible if...** - You have another primary anxiety condition (other than GAD) - You are using non-prescribed psychoactive substances or drugs - You have a condition that prevents you from safely having an MRI (such as a pacemaker or metal implant) - You are pregnant or planning to become pregnant - You are starting a new anxiety medication at the time of the study Talk to your doctor to see if this trial is right for you.