RecruitingPhase 2NCT04559217

68Ga-DOTATATE Neuroblastoma Imaging Pilot

Pilot Study of 68Ga-DOTATATE PET/CT and 123I-MIBG Scintigraphy Imaging of Neuroblastoma

Sponsor

Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Enrollment

20 participants

Start Date

Dec 6, 2021

Study Type

INTERVENTIONAL

Conditions

Neuroblastoma

Summary

Neuroblastoma is the most frequent extracranial childhood tumor, with an annual incidence of approximately 10.2 per million children. Staging of the disease can be done by different imaging strategies (CT, MRI, scintigraphy and PET/CT). Discrepancies may be observed among these different strategies resulting in different treatment strategies. The goal of this study is to assess the feasibility and safety of 68Ga-DOTATATE and to compare it to 123I-MIBG when investigating neuroblastoma.

Eligibility

Max Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This imaging study compares two types of scans in children and young adults with neuroblastoma — a cancer that commonly affects the adrenal glands and nervous system in children. The study tests whether a newer scan using gallium-68 (68Ga-DOTATATE PET/CT) can provide more accurate images than the traditional iodine-based scan (MIBG imaging). **You may be eligible if...** - You are between 1 day and 21 years old - You have newly suspected or biopsy-confirmed neuroblastoma, or a recurrence of neuroblastoma - You are already scheduled to have a standard MIBG scan - You or your parent/guardian can provide consent in French or English **You may NOT be eligible if...** - You have had another cancer in the past 5 years (other than certain skin cancers) - You are currently being treated for your tumor - You are pregnant - You have had a previous allergic reaction to somatostatin analogues - You are medically unstable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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