Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

Exclusion Criteria15

• In phone prescreen, delighted or pleased with current quality of life due to urinary symptoms.
• Indwelling catheter
• History of greater than 4 urinary tract infections per year
• Multiple sclerosis
• Significant heart, liver, kidney, pulmonary, blood, autoimmune or peripheral vascular disease
• Systolic blood pressure <90 or >170, diastolic blood pressure <50 or >110 after repeated evaluation with proper cuff. This range is the acceptable range stated in the prescribing information for sildenafil (>90/50 and <170/110)
• Active cancer
• HIV, Hepatitis B, or Hepatitis C
• Use of systemic nitrates, anabolic steroids, corticosteroids, or long acting PDE5 inhibitors in the past 1 month
• Use of short acting PDE5 inhibitors in the past 1 week
• Use of alpha blockers, anticholinergic agents, bethanechol, or other UI treatment within the past 2 weeks ( 3 weeks for long acting muscarinic receptor antagonists)
• Known allergic reaction to any agent under investigation or required by the protocol
• Females who are pregnant or lactating
• Atonic bladder or high detrusor and high pelvic floor muscle pressure based on previous cystometrogram (CMG) (on file with their provider) that would place subjects at risk for kidney injury
• Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation