Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

This large NIH study examines the long-term health effects of COVID-19 — including "long COVID" (also called PASC: Post-Acute Sequelae of SARS-CoV-2 infection). Researchers want to understand why some people recover fully while others continue to experience symptoms like fatigue, brain fog, and breathing difficulties for months or even years. The study has multiple phases, starting with surveys and progressing to detailed medical evaluations at the NIH. Participants may include people who recovered from COVID-19, those with ongoing long COVID symptoms, those with persistent symptoms after a negative COVID test, and people who had vaccine-related symptoms. Healthy volunteers who recovered from COVID-19 without lasting symptoms are also needed as comparison participants. You may be eligible if: - You are 18 years or older - You have documentation of a prior COVID-19 infection (PCR, antigen test, antibody test) - You are recovering from or have recovered from a COVID-19 infection - You speak and read English You may NOT be eligible if: - You have a history of severe psychiatric illness (psychosis, schizophrenia, bipolar disorder with psychosis) - You are currently pregnant, breastfeeding, or within one year postpartum (for in-person phases) - You have a serious pre-existing chronic illness that independently causes fatigue (e.g., heart failure, COPD, fibromyalgia) - You have a current or prior cancer diagnosis (some exceptions apply) - You are unable to travel to the NIH for the in-person evaluation phases Talk to your doctor to see if this trial is right for you.