Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A Feasibility Study

This study tests a shorter, higher-dose radiation schedule (hypofractionated radiotherapy) combined with chemotherapy for women with cervical cancer who are treated with radiation rather than surgery. The goal is to see whether this condensed schedule is feasible and safe compared to the standard longer course. **You may be eligible if...** - You are 18 years old or older - You have been diagnosed with invasive cervical cancer (squamous cell, adenocarcinoma, or adenosquamous) - Your cancer is FIGO stage IB2, IB3, IIA, or IIB — or early-stage if surgery is not an option - Your doctor has determined you are a candidate for chemoradiation with weekly cisplatin and brachytherapy (internal radiation) **You may NOT be eligible if...** - Your cancer is stage IIIA, IIIB, IVA, or IVB (more advanced stages) - You have had prior pelvic or abdominal radiation - You have inflammatory bowel disease or a connective tissue disorder (e.g., lupus, scleroderma) - You have a rare cervical cancer subtype such as small cell, sarcoma, or melanoma - You cannot have an MRI scan - You cannot tolerate cisplatin chemotherapy Talk to your doctor to see if this trial is right for you.