RecruitingPhase 3NCT06459180

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

A Phase 3 Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (TroFuse-020/GOG-3101/ENGOT-cx20)

Sponsor

Merck Sharp & Dohme LLC

Enrollment

686 participants

Start Date

Jul 24, 2024

Study Type

INTERVENTIONAL

Conditions

Cervical Cancer

Summary

This study will have two phases: a sacituzumab tirumotecan safety run-in and a Phase 3 portion. The safety run-in phase will be used to evaluate the efficacy and safety of sacituzumab tirumotecan at the dose for evaluation in the Phase 3 portion. The purpose of this study is to compare the efficacy and safety of sacituzumab tirumotecan versus treatment of physician's choice as second-line treatment for participants with recurrent or metastatic cervical cancer in the Phase 3 portion. The primary study hypotheses are that, in the Phase 3 portion, sacituzumab tirumotecan results in a superior overall survival compared to TPC in participants with high trophoblast cell surface antigen 2 (TROP2) expression level and in all participants.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new cancer drug called sacituzumab tirumotecan (MK-2870) compared to standard treatments for women whose cervical cancer has come back or spread after previous chemotherapy. **You may be eligible if...** - You are female (assigned female sex at birth), age 18 or older - You have cervical cancer that has returned or spread to other parts of the body - You have already received one round of platinum-based chemotherapy AND immunotherapy (a PD-1 or PD-L1 checkpoint inhibitor) for cervical cancer - Your cancer is still measurable on scans - You are in good general health (able to carry out light activity) **You may NOT be eligible if...** - You have significant nerve damage (numbness or tingling in hands/feet) - You have severe dry eye disease, corneal conditions, or inflammatory bowel disease - You have uncontrolled heart or stroke disease - Your cancer has spread to the brain - You have had a live vaccine within 30 days of starting the study - You have active pneumonia or a serious lung inflammation condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALSacituzumab Tirumotecan

IV infusion

DRUGPemetrexed

IV infusion

BIOLOGICALTisotumab Vedotin

IV infusion

DRUGTopotecan

IV infusion

DRUGVinorelbine

IV infusion

DRUGGemcitabine

IV infusion

DRUGIrinotecan

IV infusion

Locations(240)

USA Mitchell Cancer Institute-Clinical Trials ( Site 4126)

Mobile, Alabama, United States

Providence Alaska Medical Center ( Site 4137)

Anchorage, Alaska, United States

HonorHealth (HH) ( Site 8002)

Phoenix, Arizona, United States

Arizona Oncology Associates - HOPE ( Site 8001)

Tucson, Arizona, United States

Moores Cancer Center-Clinical Trials Office - Gynecological Oncology ( Site 4125)

La Jolla, California, United States

UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4105)

Los Angeles, California, United States

Hoag Memorial Hospital Presbyterian ( Site 4104)

Newport Beach, California, United States

Mount Sinai Comprehensive Cancer Center ( Site 4143)

Miami Beach, Florida, United States

Advent Health ( Site 4140)

Orlando, Florida, United States

Florida Cancer Specialists East ( Site 7001)

West Palm Beach, Florida, United States

Northside Hospital ( Site 4127)

Atlanta, Georgia, United States

Georgia Cancer Center at Augusta University ( Site 4112)

Augusta, Georgia, United States

Lewis Cancer and Research Pavilion ( Site 4114)

Savannah, Georgia, United States

University Medical Center New Orleans ( Site 4132)

New Orleans, Louisiana, United States

Willis Knighton Medical Center ( Site 4101)

Shreveport, Louisiana, United States

The Center of Hope ( Site 4106)

Reno, Nevada, United States

Holy Name Medical Center ( Site 4117)

Teaneck, New Jersey, United States

Optimum Clinical Research Group ( Site 4138)

Albuquerque, New Mexico, United States

Perlmutter Cancer Center NYU Langone Hospital - Long Island ( Site 4145)

Mineola, New York, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 4121)

New York, New York, United States

Duke Cancer Institute ( Site 4120)

Durham, North Carolina, United States

University of Cincinnati Medical Center ( Site 4128)

Cincinnati, Ohio, United States

The Ohio State University ( Site 4103)

Hilliard, Ohio, United States

Oklahoma Cancer Specialists and Research Institute, LLC-Clinical Research ( Site 4116)

Tulsa, Oklahoma, United States

Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007)

Eugene, Oregon, United States

Legacy Good Samaritan Medical Center-Oncology Clinical Research ( Site 4115)

Portland, Oregon, United States

Sidney Kimmel Cancer Center - Jefferson Health ( Site 4142)

Philadelphia, Pennsylvania, United States

Asplundh Cancer Pavilion ( Site 4113)

Willow Grove, Pennsylvania, United States

The West Clinic, PLLC dba West Cancer Center ( Site 4108)

Germantown, Tennessee, United States

Texas Oncology - Central/South Texas ( Site 8010)

Austin, Texas, United States

Texas Oncology - DFW ( Site 8003)

Fort Worth, Texas, United States

Houston Methodist Hospital OB/GYN ( Site 4102)

Houston, Texas, United States

Texas Oncology - San Antonio ( Site 8006)

San Antonio, Texas, United States

Texas Oncology - Northeast Texas ( Site 8009)

Tyler, Texas, United States

Texas Oncology - Gulf Coast ( Site 8008)

Webster, Texas, United States

University of Virginia Cancer Center ( Site 4123)

Charlottesville, Virginia, United States

Inova Schar Cancer Institute ( Site 4139)

Fairfax, Virginia, United States

Swedish Medical Center-Swedish Cancer Institute ( Site 4134)

Seattle, Washington, United States

Hospital Británico de Buenos Aires-Oncology ( Site 0102)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0107)

Mar del Plata, Buenos Aires, Argentina

Instituto de Oncología Angel H. Roffo ( Site 0103)

Buenos Aires, Buenos Aires F.D., Argentina

Instituto Alexander Fleming ( Site 0108)

Buenos Aires, Buenos Aires F.D., Argentina

Sanatorio Allende - Cerro-Oncology ( Site 0106)

Córdoba, Córdoba Province, Argentina

Hospital Aleman-Oncology ( Site 0100)

Buenos Aires, Argentina

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0109)

CABA, Argentina

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0104)

La Rioja, Argentina

Blacktown Hospital ( Site 3006)

Sydney, New South Wales, Australia

Campbelltown Hospital-Macarthur Cancer Therapy Centre Medical Oncology ( Site 3000)

Sydney, New South Wales, Australia

Royal Brisbane and Women's Hospital ( Site 3001)

Herston, Queensland, Australia

Monash Health-Oncology Research ( Site 3002)

Clayton, Victoria, Australia

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3005)

Melbourne, Victoria, Australia

Sir Charles Gairdner Hospital ( Site 3003)

Nedlands, Western Australia, Australia

Medizinische Universität Graz-Abteilung für Gynäkologie / Onkologie ( Site 1003)

Graz, Styria, Austria

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1000)

Innsbruck, Tyrol, Austria

Kepler Universitätsklinikum-Department for Oncology and Hematology ( Site 1002)

Linz, Upper Austria, Austria

Medizinische Universität Wien ( Site 1001)

Vienna, Austria

AZORG Campus Aalst-Moorselbaan ( Site 2905)

Aalst, Oost-Vlaanderen, Belgium

UZ Gent-Medical oncology ( Site 2901)

Ghent, Oost-Vlaanderen, Belgium

UZ Leuven-Gynecologic Oncology ( Site 2900)

Leuven, Vlaams-Brabant, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman-Medical Oncology ( Site 2904)

Belgium, Wallonne, Region, Belgium

CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 2902)

Namur, Belgium

Instituto do Câncer e Transplante de Curitiba ( Site 0205)

Curitiba, Paraná, Brazil

Hospital Moinhos de Vento-Centro de Pesquisa Clínica ( Site 0204)

Porto Alegre, Rio Grande do Sul, Brazil

Hospital do Câncer Mãe de Deus ( Site 0201)

Porto Alegre, Rio Grande do Sul, Brazil

Centro de Hematologia e Oncologia ( Site 0203)

Joinville, Santa Catarina, Brazil

IBCC - Instituto Brasileiro de Controle do Câncer-Centro de Pesquisa Clínica ( Site 0200)

São Paulo, São Paulo, Brazil

Americas Centro de Oncologia Integrado ( Site 0202)

Rio de Janeiro, Brazil

Hospital Paulistano ( Site 0209)

São Paulo, Brazil

MBAL Uni Hospital-Department of Medical Oncology ( Site 1104)

Panagyurishte, Pazardzhik, Bulgaria

MHAT - Heart and Brain ( Site 1100)

Pleven, Bulgaria

Complex Oncology Center - Plovdiv EOOD ( Site 1102)

Plovdiv, Bulgaria

BC Cancer Kelowna ( Site 4007)

Kelowna, British Columbia, Canada

BC Cancer Surrey ( Site 4006)

Surrey, British Columbia, Canada

BC Cancer Victoria ( Site 4008)

Victoria, British Columbia, Canada

Royal Victoria Regional Health Centre ( Site 4009)

Barrie, Ontario, Canada

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 4003)

Hamilton, Ontario, Canada

Centre Hospitalier de l'Université de Montréal ( Site 4001)

Montreal, Quebec, Canada

McGill University Health Centre ( Site 4000)

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 4002)

Québec, Quebec, Canada

FALP-UIDO ( Site 0300)

Santiago, Region M. de Santiago, Chile

Pontificia Universidad Catolica de Chile ( Site 0302)

Santiago, Region M. de Santiago, Chile

ONCOCENTRO APYS-ACEREY ( Site 0303)

Viña del Mar, Valparaiso, Chile

Anhui Provincial Cancer Hospital-Gynecological Oncology ( Site 5040)

Hefei, Anhui, China

Anhui Provincial Hospital ( Site 5011)

Hefei, Anhui, China

Beijing Peking Union Medical College Hospital ( Site 5045)

Beijing, Beijing Municipality, China

Chongqing University Cancer Hospital ( Site 5003)

Chongqing, Chongqing Municipality, China

Fujian Provincial Cancer Hospial ( Site 5012)

Fuzhou, Fujian, China

The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 5027)

Xiamen, Fujian, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 5001)

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center-Internal medicine ( Site 5006)

Guangzhou, Guangdong, China

Affiliated Hospital of Guangdong Medical University ( Site 5004)

Zhanjiang, Guangdong, China

Guangxi Medical University Affiliated Tumor Hospital ( Site 5016)

Nanning, Guangxi, China

Hainan General Hospital ( Site 5032)

Haikou, Hainan, China

Harbin Medical University Cancer Hospital ( Site 5010)

Harbin, Heilongjiang, China

The First Affiliated Hospital of Xinxiang Medical University-Oncology ( Site 5041)

Xinxiang, Henan, China

Henan Cancer Hospital ( Site 5026)

Zhengzhou, Henan, China

Wuhan Union Hospital ( Site 5020)

Wuhan, Hubei, China

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 5019)

Wuhan, Hubei, China

Hunan Cancer Hospital ( Site 5021)

Changsha, Hunan, China

Xiangya Hospital Central South University ( Site 5009)

Changsha, Hunan, China

Jiangsu Province Hospital-Oncology Department ( Site 5018)

Nanjing, Jiangsu, China

Jiangxi Maternal and Child Health Hospital ( Site 5031)

Nanchang, Jiangxi, China

Jilin Province Tumor Hospital ( Site 5036)

Changchun, Jilin, China

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 5007)

Xi'an, Shaanxi, China

Shandong Cancer Hospital ( Site 5014)

Jinan, Shandong, China

LinYi Cancer Hospital-Gastrology department ( Site 5039)

Linyi, Shandong, China

Obstetrics & Gynecology Hospital of Fudan University ( Site 5015)

Shanghai, Shanghai Municipality, China

Shanxi Cancer Hospital ( Site 5043)

Taiyuan, Shanxi, China

West China Second University Hospital, Sichuan University ( Site 5017)

Chengdu, Sichuan, China

Sichuan Cancer hospital-Oncology ( Site 5030)

Chengdu, Sichuan, China

Yunnan Province Cancer Hospital-Gynecology Department ( Site 5005)

Kunming, Yunnan, China

Women s Hospital School of Medicine Zhejiang University ( Site 5022)

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital ( Site 5008)

Hangzhou, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University ( Site 5033)

Wenzhou, Zhejiang, China

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0403)

Bogotá, Bogota D.C., Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0401)

Valledupar, Cesar Department, Colombia

Instituto Nacional De Cancerologia-Oncología Clínica ( Site 0404)

Bogota, Cundinamarca, Colombia

IMAT S.A.S ( Site 0402)

Montería, Departamento de Córdoba, Colombia

Oncologos del Occidente ( Site 0405)

Pereira, Risaralda Department, Colombia

Fundación Valle del Lili ( Site 0406)

Cali, Valle del Cauca Department, Colombia

Rigshospitalet-Dept. of Oncology ( Site 1300)

Copenhagen, Capital Region, Denmark

Aarhus Universitetshospital, Skejby ( Site 1301)

Aarhus, Central Jutland, Denmark

Odense Universitetshospital-Department of oncology ( Site 1302)

Odense C, Region Syddanmark, Denmark

Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1404)

Tampere, Pirkanmaa, Finland

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1401)

Turku, Southwest Finland, Finland

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1400)

Helsinki, Uusimaa, Finland

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1503)

Bordeaux, Aquitaine, France

CENTRE LEON BERARD ( Site 1505)

Lyon Cedex08, Auvergne-Rhône-Alpes, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1508)

Clermont-Ferrand, Auvergne, France

Hopitaux Universitaires de Strasbourg ( Site 1501)

Strasbourg, Bas-Rhin, France

Institut Paoli-Calmettes ( Site 1504)

Marseille, Bouches-du-Rhone, France

Hôpital Privé Des Côtes d'Armor ( Site 1510)

Plérin, Cotes-d Armor, France

CHU Besançon ( Site 1507)

Besançon, Franche-Comte, France

Oncopole Claudius Regaud ( Site 1502)

Toulouse, Haute-Garonne, France

Institut Regional du Cancer Montpellier ( Site 1511)

Montpellier, Herault, France

Hôpital privé du Confluent SAS ( Site 1509)

Nantes, Loire-Atlantique, France

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1506)

Paris, France

Gustave Roussy ( Site 1512)

Villejuif, Île-de-France Region, France

Universitaetsklinikum Heidelberg Nationales Centrum fuer Tumorerkrankungen ( Site 1612)

Heidelberg, Baden-Wurttemberg, Germany

SLK-Kliniken Heilbronn ( Site 1617)

Heilbronn, Baden-Wurttemberg, Germany

Diakonie-Klinikum Schwaebisch-Hall gGmbH Frauenklinik ( Site 1614)

Schwäbisch Hall, Baden-Wurttemberg, Germany

Klinikum der Universität München Großhadern-Klinik und Poliklinik für Frauenheilkunde und Geburtshi ( Site 1605)

Munich, Bavaria, Germany

Universitätsklinikum Marburg ( Site 1604)

Marburg, Hesse, Germany

Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1607)

Düsseldorf, North Rhine-Westphalia, Germany

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Gynäkologie und Gynäkologische Onko ( Site 1600)

Essen, North Rhine-Westphalia, Germany

Universitaetsklinikum Essen ( Site 1613)

Essen, North Rhine-Westphalia, Germany

Klinikum Worms ( Site 1619)

Worms, Rhineland-Palatinate, Germany

Universitaetsklinikum des Saarlandes ( Site 1618)

Homburg, Saarland, Germany

Universitaetsklinikum Hamburg-Eppendorf-Department of Gynecology ( Site 1611)

Hamburg, Germany

Aretaieio Hospital ( Site 1700)

Athens, Attica, Greece

Mitera Hospital ( Site 1702)

Athens, Attica, Greece

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1703)

Chaïdári, Attica, Greece

Agios Andreas Hospital Patras ( Site 1701)

Patras, Peloponnese, Greece

Cork University Hospital ( Site 1900)

Cork, Ireland

Mater Misericordiae University Hospital ( Site 1901)

Dublin, Ireland

St. James's Hospital-Cancer clinical trials office ( Site 1902)

Dublin, Ireland

Rambam Health Care Campus ( Site 2002)

Haifa, Israel

Edith Wolfson Medical Center ( Site 2003)

Holon, Israel

Hadassah Medical Center ( Site 2000)

Jerusalem, Israel

Sheba Medical Center ( Site 2001)

Ramat Gan, Israel

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-DEPARTMENT OF EXPERIMENTAL, DIAGNOSTIC ( Site 2105)

Bologna, Emilia-Romagna, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2107)

Milan, Lombardy, Italy

Ospedale Humanitas San Pio X ( Site 2113)

Milan, Lombardy, Italy

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2111)

Monza, Lombardy, Italy

Humanitas University ( Site 2112)

Rozzano, Milano, Italy

Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 2100)

Turin, Piedmont, Italy

Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2110)

Brescia, Italy

Ospedale Cannizzaro ( Site 2104)

Catania, Italy

Ospedale San Raffaele. ( Site 2106)

Milan, Italy

Istituto Europeo di Oncologia IRCCS ( Site 2108)

Milan, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2103)

Naples, Italy

Istituto Oncologico Veneto IRCCS ( Site 2109)

Padova, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2102)

Roma, Italy

Aichi Cancer Center ( Site 5110)

Nagoya, Aichi-ken, Japan

National Cancer Center Hospital East ( Site 5113)

Kashiwa, Chiba, Japan

National Hospital Organization Shikoku Cancer Center ( Site 5109)

Matsuyama, Ehime, Japan

Ehime University Hospital ( Site 5102)

Tōon, Ehime, Japan

Kurume University Hospital ( Site 5105)

Kurume, Fukuoka, Japan

Gunma Prefectural Cancer Center ( Site 5116)

Ohta, Gunma, Japan

Hokkaido University Hospital ( Site 5106)

Sapporo, Hokkaido, Japan

University of Tsukuba Hospital ( Site 5114)

Tsukuba, Ibaraki, Japan

Iwate Medical University Hospital ( Site 5112)

Shiwa-gun, Iwate, Japan

Saitama Medical University International Medical Center ( Site 5117)

Hidaka, Saitama, Japan

Shizuoka Cancer Center ( Site 5107)

Sunto-gun,, Shizuoka, Japan

National Cancer Center Hospital ( Site 5108)

Chūō, Tokyo, Japan

Cancer Institute Hospital of JFCR ( Site 5111)

Koto, Tokyo, Japan

The Jikei University Hospital ( Site 5118)

Minato, Tokyo, Japan

Keio University Hospital ( Site 5101)

Shinjyuku, Tokyo, Japan

National Hospital Organization Kyushu Cancer Center ( Site 5104)

Fukuoka, Japan

Kagoshima City Hospital ( Site 5115)

Kagoshima, Japan

Niigata Cancer Center Hospital ( Site 5100)

Niigata, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 5103)

Osaka, Japan

University Malaya Medical Centre ( Site 3102)

Lembah Pantai, Kuala Lumpur, Malaysia

Sunway Medical Centre ( Site 3105)

Petaling Jaya, Selangor, Malaysia

Pantai Hospital Kuala Lumpur ( Site 3100)

Kuala Lumpur, Malaysia

Penang Adventist Hospital ( Site 3101)

Pulau Pinang, Malaysia

CENEIT Oncologicos ( Site 0507)

Mexico City, Mexico City, Mexico

Oncare - Unidad Valle ( Site 0509)

San Pedro Garza García, Nuevo León, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 0505)

Oaxaca City, Oaxaca, Mexico

Centro de Investigación Oncológica Galerías SC ( Site 0508)

Aguascalientes, Mexico

Centro de Atención e Investigación Cardiovascular del Potosí ( Site 0506)

San Luis Potosí City, Mexico

Radboudumc-Medical Oncology ( Site 2202)

Nijmegen, Gelderland, Netherlands

Catharina Ziekenhuis-Oncology ( Site 2203)

Eindhoven, North Brabant, Netherlands

Amsterdam UMC, locatie VUmc ( Site 2201)

Amsterdam, North Holland, Netherlands

Erasmus Medisch Centrum-Medical Oncology ( Site 2200)

Rotterdam, South Holland, Netherlands

University Medical Center Groningen ( Site 2204)

Groningen, Netherlands

Oslo universitetssykehus, Radiumhospitalet ( Site 2300)

Oslo, Norway

Uniwersytecki Szpital Kliniczny w Poznaniu-Klinika Ginekologii Onkologicznej ( Site 2404)

Poznan, Greater Poland Voivodeship, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2400)

Warsaw, Masovian Voivodeship, Poland

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2402)

Bialystok, Podlaskie Voivodeship, Poland

UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 0601)

San Juan, Puerto Rico

National University Hospital ( Site 3301)

Singapore, Central Singapore, Singapore

National Cancer Centre Singapore ( Site 3300)

Singapore, Central Singapore, Singapore

Seoul National University Hospital ( Site 3403)

Seoul, South Korea

Severance Hospital, Yonsei University Health System ( Site 3402)

Seoul, South Korea

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3401)

Seoul, South Korea

Samsung Medical Center ( Site 3400)

Seoul, South Korea

HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2509)

Barcelona, Catalonia, Spain

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2508)

L'Hospitalet de Llobregat, Catalonia, Spain

Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 2507)

Girona, Gerona, Spain

Clinica Universidad de Navarra ( Site 2510)

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2502)

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2506)

Madrid, Madrid, Comunidad de, Spain

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2503)

Valencia, Valenciana, Comunitat, Spain

HOSPITAL CLINICO DE VALENCIA ( Site 2505)

Valencia, Valenciana, Comunitat, Spain

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2500)

Barcelona, Spain

Hospital Universitario Reina Sofia-Oncologia Medica ( Site 2501)

Córdoba, Spain

Hospital Universitario La Paz-Oncología Médica ( Site 2504)

Madrid, Spain

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2602)

Lund, Skåne County, Sweden

Karolinska Universitetssjukhuset Solna ( Site 2601)

Stockholm, Stockholm County, Sweden

Akademiska sjukhuset ( Site 2603)

Uppsala, Uppsala County, Sweden

Universitetssjukhuset i Linköping ( Site 2600)

Linköping, Östergötland County, Sweden

University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 2701)

Basel, Canton of Basel-City, Switzerland

Inselspital Bern-Oncology ( Site 2700)

Bern, Switzerland

ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 2807)

London, England, United Kingdom

Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 2801)

Sutton, England, United Kingdom

Gartnavel General Hospital-Clinical Trials Unit ( Site 2800)

Glasgow, Glasgow City, United Kingdom

University College London Hospital ( Site 2805)

London, London, City of, United Kingdom

St James's University Hospital ( Site 2804)

Leeds, United Kingdom

The Christie NHS Foundation Trust-Research and Development ( Site 2802)

Manchester, United Kingdom

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NCT06459180

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