RecruitingNot ApplicableNCT04590690

Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery

Sponsor

University of Chicago

Enrollment

28 participants

Start Date

Nov 1, 2020

Study Type

INTERVENTIONAL

Conditions

Bariatric Surgery Candidate

Summary

This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery. Subjects will be asked to follow a special (clinic-provided) diet for six days and come to a research clinic for 3 study visits.

Eligibility

Min Age: 18 YearsMax Age: 130 Years

Inclusion Criteria2

Participants without history of stone disease, family history of stone disease
Participants pre-bariatric surgery who are approved and planned for surgery in the Bariatric Surgery Center at University of Chicago Medicine.

Exclusion Criteria3

Patients with primary renal diseases or renal impairment (eGFR < 90)
Patients with known bladder voiding problems
Patients with 25-vitamine D deficiency, as defined by level < 25ng/mL

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Interventions

OTHERSpecial diet

The research clinic will provide subjects with a special diet for six days. After six days of isocaloric sodium, calcium and fluid intake, the study team will analyze three sequential 24-hour urine compositions including supersaturation of calcium oxalate, calcium, and urine volume, as well as stool collections. We will also evaluate components of 24-hour urine composition, specifically supersaturation, and the microbial contributions to urinary composition in 72-hour stool samples simultaneously collected using shot-gun metagenomic sequencing in men and women 1 year after surgery.