RecruitingNCT04593498

Excessive Supraventricular Activity and Atrial Fibrillation

Detection of Atrial Fibrillation in Patients With Excessive Supraventricular Activity


Sponsor

Karolinska Institutet

Enrollment

250 participants

Start Date

Nov 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.


Eligibility

Min Age: 70 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study monitors people who have an unusually high number of extra heartbeats (called supraventricular ectopic beats) to see whether they are at increased risk of developing atrial fibrillation — an irregular heart rhythm that can raise stroke risk. The goal is to better understand who needs closer follow-up or preventive treatment. **You may be eligible if...** - You have a heart monitor (Holter) recording showing 30 or more extra beats per hour, or a run of at least 20 rapid beats - You are between 70 and 89 years old **You may NOT be eligible if...** - You are under 70 or over 89 years old - You already have atrial fibrillation or atrial flutter - You are already on long-term blood thinners - You have an implanted cardiac device (such as a pacemaker) - You have severe heart failure or a very low heart pumping function (ejection fraction 30% or less) - You have severe heart valve disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTHolter recording

Holter recording with Zenicor Flex ECG during 14 days.

DIAGNOSTIC_TESTEchocardiography (Echo)

Echocardiography: Comprehensive transthoracic echocardiography with special focus on atrial dimension and function.

DIAGNOSTIC_TESTBlood sample

Blood sample: 2 x 10 ml EDTA plasma sampled from venous blood at index and at 21 months. Troponin T, NTproBNP, Na, K, Creatinine. Sample for Biobank for future analysis.

DIAGNOSTIC_TEST24 hour ambulatory blood pressure monitoring And Arteriograph

To assess artery stiffness.


Locations(1)

Danderyd Hospital

Stockholm, Sweden

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NCT04593498


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