New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Utah
100 participants
Mar 3, 2017
INTERVENTIONAL
Conditions
Summary
This study's main specific aims are; 1. To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion methods, as well as fibrosis quantification, longitudinal strain, and phase contrast imaging for flow. 2. Test the new methods for identifying the clinical task of characterizing HFpEF.
Eligibility
Plain Language Summary
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Interventions
Adenosine: 0.14mg/kg/min for 6 min. IV injection for MRI perfusion
0.4mg in 5ml, given as a rapid (10 seconds) IV injection for MRI perfusion.
O-15 labeled radioactive water: Up to 50mCi IV injection at rest and again at hyperemia for PET Imaging
Pass dynamic contrast enhanced MRI scans will be performed at rest and during hyperemia caused by either adenosine infusion or regadenoson
Quantitative PET imaging with O-15 labeled radioactive water will be given at a different day
Locations(1)
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NCT04600115