Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome

This study examines a specific type of abnormal cell — called a clonogenic epithelial cell — in people who have developed a lung complication called bronchiolitis obliterans syndrome (BOS) after a stem cell or lung transplant. BOS causes progressive lung scarring and breathing decline, and researchers hope that studying these cells will help detect it earlier in future patients. Adults who have had an allogeneic stem cell transplant (at MD Anderson) or a lung transplant (at Houston Methodist) and who are already scheduled for a bronchoscopy procedure may be eligible. Participation involves additional airway brushings and nasal swabs collected during the standard bronchoscopy, plus a review of medical records, with follow-up for up to one year. This summary was generated with AI assistance and is intended to help patients understand the study in plain language.