RecruitingNCT04621201

Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas

Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas (SAR-GEN_ITA): a Multicenter Prospective Study

Sponsor

Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

Enrollment

120 participants

Start Date

Dec 6, 2018

Study Type

OBSERVATIONAL

Conditions

Diagnosed or Relapsed/Refractory Sarcomas

Summary

Bone and soft tissue sarcomas represent about 7-12% of all pediatric cancer and are a heterogeneous group of tumors arising in connective tissues embryologically derived from the mesenchyme. For some of these tumors relapse and mortality rates are still significantly high. Therefore, further studies are needed to better understand pathogenetic processes underlying sarcomas to offer new and more effective treatments. Next generation sequencing (NGS) has opened new frontiers for cancer research allowing to identify somatic or constitutional mutations known or yet unknown with the aim to better understand carcinogenesis. The establishment of the genomic profile of the tumor could also help clinicians to personalize patients treatment based on their genetic and molecular alterations.

Eligibility

Max Age: 24 Years

Plain Language Summary

Simplified for easier understanding

This study is analyzing the genetic makeup of bone and soft tissue cancers (sarcomas — specifically osteosarcoma, Ewing sarcoma, and synovial sarcoma) in children, teenagers, and young adults. By understanding the genetic changes in these tumors, researchers hope to develop better targeted treatments. **You may be eligible if...** - You are 24 years old or younger - You have been confirmed to have osteosarcoma, Ewing sarcoma, or synovial sarcoma at initial diagnosis or relapse - Fresh tumor tissue and a blood sample are available - You or your parent/guardian can provide written consent **You may NOT be eligible if...** - You have an active HIV, Hepatitis B, or Hepatitis C infection - You have another condition that the investigator believes would interfere with participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERobservation and biopsy

biopsy

Locations(10)

AOU Città della Salute e della Scienza di Torino - Presidio Infantile Regina Margherita

Torino, Turin, Italy

Istituto Ortopedico Rizzoli

Bologna, Italy

Policlinico S.Orsola-Malpighi

Bologna, Italy

Azienda ospedaliero-universitaria Meyer

Florence, Italy

Istituto Giannina Gaslini

Genova, Italy

Istituto Nazionale Tumori

Milan, Italy

Presidio Ospedaliero Gaetano Pini | ASST Pini-CTO

Milan, Italy

Fondazione I.R.C.C.S. Policlinico San Matteo

Pavia, Italy

Istituti fisioterapici Ospitalieri - Istituto Tumori Regina Elena e Istituto Dermatologico San Gallicano

Roma, Italy

IRCCS materno infantile Burlo Garofolo

Trieste, Italy

View Full Details on ClinicalTrials.gov

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NCT04621201