Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment

This study is testing whether a protein called S100A7 can be used as a marker in tissue biopsies to help identify very early oral cancer or precancerous changes in the mouth before they progress. It is a laboratory/tissue analysis study that does not involve a new treatment. **You may be eligible if...** - You had a biopsy of a suspicious lesion in the mouth to rule out oral cancer or precancerous changes (oral dysplasia) - Biopsy tissue is available for analysis **You may NOT be eligible if...** - Your biopsy showed an existing oral squamous cell carcinoma (established mouth cancer) at the same time as the suspicious lesion Talk to your doctor to see if this trial is right for you.