Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

This study is testing an intensive combined treatment of chemotherapy and radiation therapy for people with a type of brain tumor called IDH wildtype glioma (also known as molecular glioblastoma), which is a high-grade tumor that behaves aggressively even if it was originally diagnosed as lower-grade. **You may be eligible if...** - You have been diagnosed with a glioma (brain tumor) that is IDH wildtype, confirmed by molecular testing — including types such as diffuse astrocytoma, oligodendroglioma, or similar - You have had surgery, and your post-operative MRI is available for radiation planning - You are in reasonably good functional health (Karnofsky score ≥ 70) - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your tumor is IDH mutant (a different type of glioma with better prognosis) - Your overall health is too poor to receive chemoradiation - You have already received radiation to the brain area being treated Talk to your doctor to see if this trial is right for you.