The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

This study is testing whether a stool DNA test (a non-invasive test that detects cancer-related DNA in a stool sample) can be used to monitor colorectal cancer survivors for signs of cancer recurrence, as an alternative or supplement to standard colonoscopy surveillance. **You may be eligible if...** - You have been diagnosed with stage I, II, or III colon or rectal cancer - You had a bowel resection (surgical removal) as part of your treatment - You had a colonoscopy before your surgery - You understand and can consent to the study in English **You may NOT be eligible if...** - You have stage IV (metastatic) colorectal cancer - You had your entire colon or rectum removed - You have inflammatory bowel disease (Crohn's or ulcerative colitis) - You have a hereditary colorectal cancer syndrome (like Lynch syndrome or familial polyposis) - You had large precancerous polyps that were not fully removed Talk to your doctor to see if this trial is right for you.