RecruitingNCT04624555

The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

Sponsor

Case Comprehensive Cancer Center

Enrollment

50 participants

Start Date

Oct 31, 2022

Study Type

OBSERVATIONAL

Conditions

Adenocarcinoma of the Rectum Stage III Colorectal Cancer Adenocarcinoma of the Colon Stage II Colorectal Cancer Stage I Colorectal Cancer

Summary

The purpose of this research study is to determine whether testing of stool for a panel of markers will enable us to detect polyps and cancer compared to standard testing.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Diagnosis of stage I, II or III adenocarcinoma of the colon or rectum
Receipt of preoperative colonoscopy
Receipt of bowel resection; use of adjuvant chemotherapy or radiation therapy as clinically indicated

Exclusion Criteria8

Stage IV colorectal cancer
Surgical treatment with subtotal colectomy or total proctocolectomy
Diagnosis of inflammatory bowel disease (ulcerative colitis or Crohn's disease)
Diagnosis of polyposis syndrome including Lynch syndrome or familial polyposis
Presence of advanced adenomas (1 cm or larger, villous features and/or high grade dysplasia) that were not removed at the preoperative colonoscopy or contained in the resection specimen.
Inability to provide informed consent
Inability to understand spoken and written English
Medical comorbidities that would be contraindications to sedation or that would preclude any benefit of routine surveillance post-resection. These would be at the discretion of the participant's providers.