RecruitingNCT04629053

Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia

Determining the Causes and Outcomes of Febrile Illness in Health Care Facilities in Rural South and Southeast Asia, as Part of the South and Southeast Asian Community-based Trials Network (SEACTN). Work Package B (WP-B).

Sponsor

University of Oxford

Enrollment

7,200 participants

Start Date

Jun 21, 2022

Study Type

OBSERVATIONAL

Conditions

Acute Febrile Illness

Summary

This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in Laos, Myanmar, Thailand, the Thai-Myanmar border region, and Bangladesh and presenting with acute febrile illnesses (≤ 14 days duration) to participating health facilities. This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z

Eligibility

Min Age: 29 Days

Inclusion Criteria4

The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
Aged \> 28 days (day of birth = Day 1);
Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR \< 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
Onset of illness ≤ 14 days

Exclusion Criteria4

Accident or trauma is the cause for the patient's presentation;
Presentation ≤ 3 days after routine immunisations
Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
The treating healthcare worker's decision is to send the patient home following initial assessment.

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