RecruitingNCT04648124

VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies


Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Enrollment

200 participants

Start Date

Jan 4, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.


Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • Patient over 18 years old
  • Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
  • Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
  • Express consent to participate in the study
  • Affiliate or beneficiary of a social security scheme

Exclusion Criteria5

  • Patient benefiting from a legal protection measure
  • Pregnant or breastfeeding woman
  • Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
  • Other additional ocular pathology that can significantly affect vision
  • Recent eye surgery less than 3 months old

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Interventions

DEVICEIRMf-r (séquence resting state)

Functional MRI of functional brain networks


Locations(1)

Fondation Adolphe de Rothschild

Paris, PARIS, France

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NCT04648124